Klatte et al. [5] conducted a reassessment of 75 RCC with morphological features suggestive of TFE3 translocation, revealing that 17 cases exhibited positive TFE3 IHC, while only 2 cases (2.6%) were genetically confirmed for the translocation through FISH or polymerase chain reaction (PCR). The gene discussed is TFE3; the disease is renal cell carcinoma.