TFE3-rearranged-RCC exhibited a significant higher recurrence rate compared to ccRCC (50% vs 18.8%) and multivariate analysis revealed that TFE3 rearrangement, along with tumor size and metastasis, was an independent prognostic factor for recurrence (HR = 4.6; 95% CI 1.1-21.2; p = 0.05). This evidence concerns the gene TFE3 and neoplasm.