ALB and cancer: Additionally, albumin-coated NPs hold significantinterest as drug delivery vehicles for cancer therapy.6,56−59 Through experimental and computational approaches, we found thatboth native and cationic albumin interact with heparin, a model GAG,while such interactions are absent in the case of anionic albumin.Moreover, cell uptake experiments revealed that the glycocalyx caneither facilitate or hinder NP internalization depending on the typeof albumin coating.