Consistently, a higher proportion of SIINFEKL (OVA 257–264)-specific TCR-expressing CD8 T cells infiltrated B16F10-OVA melanoma in H2-Aacit/cit mice than in WT mice (Fig. S2 K), suggesting that tumor antigen-specific immune responses were more vigorous in H2-Aacit/cit mice. This evidence concerns the gene CD8A and melanoma.