To assess whether H2-Aa–deficient cDC1 mediated the tumor suppressive effect observed in H2-Aacit/cit mice, we utilized an Xcr1-cre driver that is largely restricted to the cDC1 lineage (Ferris et al., 2020; Lanca et al., 2022; Wohn et al., 2020). This evidence concerns the gene MPPE1 and neoplasm.