For ALS, the investigation brought to light a positive causal effect of two cytokines—Hepatocyte growth factor (OR = 1.1291, p = 0.0304) and Tumour necrosis factor ligand superfamily member 12 (OR = 1.0981, p = 0.0163), and a negative causal effect of five others, among them C‐X‐C motif chemokine 10 (OR = 0.8862, p = 0.0071), C‐X‐C motif chemokine 11 (OR = 0.9034, p = 0.0316), Interleukin‐2 receptor subunit beta (OR = 0.8788, p = 0.0486), T‐cell surface glycoprotein CD5 (OR = 0.8885, p = 0.0216) and Transforming growth factor‐alpha (OR = 0.8630, p = 0.0298). This evidence concerns the gene HGF and amyotrophic lateral sclerosis.