CRP and blood coagulation disease: Patients with end-stage liver disease often present with coagulopathy and low platelet levels, and the severity of liver disease is closely related.[16] Our results found a significant difference in the rate of change in CRP, and the ratio after to before of N% between the 2 groups (P < .05), indicating a possible association between CRP and N% with disease progression in HBV-Pre.ACLF.