Screening showed that these pathways mainly involve Rheumatoid arthritis, Bladder cancer, Toll-like receptor signaling pathway, ABC transporters, Pathways in cancer, Breast cancer, IL-17 signaling pathway, Folate biosynthesis, Complement and coagulation cascades, ECM-receptor interaction, Endocrine resistance, Human papillomavirus infection, nonalcoholic fatty liver disease, Mitophagy – animal, Prolactin signaling pathway, Phagosome, TNF signaling pathway, PI3K- Akt signaling pathway, Fat digestion and absorption, MicroRNAs in cancer (Fig. 5C and D). The gene discussed is TNF; the disease is breast carcinoma.