HCRT and major depressive disorder: his finding underscores the role of the orexin system in salt-sensitive hypertension.[30,31] Orexins play a crucial role in regulating the neurobiological systems that respond to stressful stimuli, with alterations in their levels observed in stress-related psychiatric disorders such as major depressive disorder and anxiety disorders.[13,32] Consequently, orexins present themselves as potential targets for the treatment of these disorders.[33]