TF and Infertility: Epidemiological studies have observed that women with unexplained infertility often have lower transferrin saturation and mean corpuscular hemoglobin.[13] Profound iron deficiency is thought to be a significant factor in unexplained infertility cases.[14] However, a study by Skalnaya et al[15] found no notable difference in serum iron levels between healthy individuals and pregnant women, but a 13% increase in women who experienced miscarriages compared to those who did not.