A multicenter randomized controlled trial showed no significant improvement in endothelial function or atherosclerosis in patients with obstructive sleep apnea.[7] In addition, studies have shown that obstructive sleep apnea is closely related to PCSK9, and patients with sleep apnea who take statins have elevated PCSK9.[8] A PCSK9 inhibitor lowers serum LDL-C concentrations.[9] However, research on the risk of sleep apnea associated with lipid-lowering drugs is lacking, and further investigations on the effects of statins and PCSK9 inhibitors on this disease are needed. This evidence concerns the gene PCSK9 and atherosclerosis.