NFKB1 and triple-A syndrome: In 2015, Shi explored the role of Tregs in an Ang-II induced AAA model and suggested that Tregs protect against AAA in humans and in experiments.[25] In his recent research, Shi suggested that eosinophils effectively prevented AAA formation by regulating macrophage polarization and inhibiting the activation of NF-κB signaling pathway.[26] Professor Upchurch, Gilbert R from University of Florida was the representative author who mainly focused on the clinical research of AAA.