In addition, it is known that both HT and obesity are linked to low-level chronic inflammation, and some common immune cytokines such as TNF-α and IL-6 are increased.[13] In our study, similar to the literature, we found that HT patients with high anti-TPO levels had higher BMI levels than both the control group and other HT patients with low antibody titers. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.