In a meta-analysis of prospective cohort studies involving 4413 patients with breast cancer, higher levels of 25(OH)D (>75 nmol/L) were found to be associated with a decreased likelihood of mortality.[38] Although this study establishes the optimal 25(OH)D cutoff for precise evaluations, it was unable to further categorize hormone receptor status. This evidence concerns the gene NR4A1 and breast cancer.