CD274 and central nervous system cancer: SOX2+ CD45- cells (identified as glioma-stem cells) accounted for 22.6% ± 8.0% of all live cells and were largely PD-L1 positive cells (PD-1+ vs PD-L1+ vs PD-1+ PD-L1+; 3.1% ± 1.2% vs 45.6% ± 4.8% vs 19.0% ± 2.7%; Figure 3C and D).