HSPA5 and lung cancer: For the miRNA expression data, the top-ranked hsa-mir-199a contained the GRP78 gene in its target genes, and previous studies have confirmed that the overexpression of hsa-mir-199a-5p was related to the downregulation of GRP78 gene expression, and, in nonsmall cell lung cancer, GRP78 gene expression was significantly upregulated [38], confirming that hsa-mir-199a was an miRNA closely related to lung cancer.