Several clinical and biological parameters have been assessed in relation to disease duration in prion disease (specifically in Creutzfeldt–Jacob disease or CJD), including age at symptom onset, sex, codon 129 genotype, PrPSc molecular subtype,19, 23, 24 clinical presentation,4, 25 and CSF‐ and blood‐based biomarkers of neurodegeneration (i.e., neurofilament chain and total‐Tau, 14‐3‐3).4, 24, 26, 28. Here, MAPT is linked to prion disease.