Therefore, In the current study, we investigated the regulatory influence of the 21‐day treatment of probiotic supplementation as an add‐on therapy with BRV, an SV2A modulator at the dose of 10 mL/kg and 10 mg/kg, respectively on the progression of the epileptogenic process, associated electrophysiological and behavioral arrests, redox stress and neurodegeneration in an animal model of PTZ‐induced generalized epilepsy. This evidence concerns the gene SV2A and generalized epilepsy.