Within the framework of cancer neuroscience, research has illuminated that the secretion of BDNF and IGF‐1, coupled with direct synaptic interactions between glutamatergic and GABAergic neurons and OPCs, plays a crucial role in the malignant transformation of OPCs into glioma cells [43, 46, 79, 186, 187, 188, 189, 190]. The gene discussed is BDNF; the disease is glioma.