In 2015, a milestone was achieved when a team led by Professor Michelle Monje from Stanford University identified the driver gene Neurolign‐3 (NLGN3), establishing a link between cortical neuron activity and the proliferation of high‐grade gliomas (HGGs), thereby illustrating the influence of neuronal activity on brain tumor growth [27]. Here, NLGN3 is linked to central nervous system cancer.