Mechanistically, BDNF, upon binding to TrkB, escalates the transport of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA) receptors (AMPAR) to the glioma cell membrane, increases calcium ion flux, intensifies and prolongs electrical signaling, and subsequently boosts the depolarization amplitude of glioma cell membranes, ultimately promoting glioma cell mitosis [44, 77, 78]. The gene discussed is NTRK2; the disease is glioma.