To investigate whether ischemia-induced endogenous Nrf2/HO-1 axis activation in MG exerted a protective effect in preventing excessive BBB disruption in the ischemic brain after stroke, we assessed the level of BBB disruption in the ischemic brains of Cx3cr1CreERT2/+ and Nrf2fl/fl-Cx3cr1CreERT2/+ MCAO mice. Here, HMOX1 is linked to stroke disorder.