To determine whether Nrf2 knockdown-mediated HO-1 attenuation modulated MG phenotypes in the ischemic brain, we assessed the frequency of CD68/IL-1β- and CD206-expressing MG to assess the inflammatory and anti-inflammatory phenotypes of MG, respectively, in male and female Nrf2fl/fl-Cx3cr1CreERT2/+ and Cx3cr1CreERT2/+ MCAO mice. The gene discussed is HMOX1; the disease is myasthenia gravis.