Beside the HLA-G high evasion phenotype, Pfannstiel et al., Erlmeier et al, and Zhou et al. identified another subgroup of highly T cell infiltrated MIBC with a predominant infiltration by activated T cells, T cells with preserved capacity for tumor cell killing and reduced presence or absence of immune inhibitory immune checkpoint proteins (highly inflamed cytotoxic environment) as well as a reduced myeloid cell component resulting in significantly improved outcome rates of patients (11, 13, 69). This evidence concerns the gene HLA-G and neoplasm.