While many MIBC with Ba/Sq molecular subtypes exhibit immune infiltrates consisting of CD8+ cytotoxic T lymphocytes (CTL), NK cells and macrophages (6), especially those with high HLA-G tumor cell expression belonged to the immune evasive “Evasion phenotype” that is characterized by a T-cell exhausted and myeloid dominated TIME. The gene discussed is CD8A; the disease is neoplasm.