Thus, upregulation of HLA-G tumor cell expression might be a counter-regulatory mechanism that 1) limits the TIME infiltration of CD8 and NK cells, 2) exhausts present effector T cells and NK cells via recruitment of immunosuppressive myeloid cells and regulatory T-cells, and 3) increases the immunosuppressive capacity of myeloid cells (46, 47). The gene discussed is HLA-G; the disease is neoplasm.