To further investigate the immunological features of HLA-G expressing or negative tumors we correlated HLA-G protein expression with spatially organized MIBC immune phenotypes that were described by Pfannstiel et al. using a hierarchical cluster analysis based on T-cell, NK-cell, and macrophage infiltration as well as the distribution of PD-L1 expression on immune and tumor cells (11). The gene discussed is HLA-G; the disease is neoplasm.