This is in line with our observations, that immune cells in the TIME of HLA-G high MIBC – especially of evasion phenotype MIBCs- exhibited an upregulation of crucial immune checkpoint proteins like TIGIT, PD-L1, LAG3, and CTLA-4 on tumor cells (PD-L1) and immune cells (all proteins). The gene discussed is LAG3; the disease is neoplasm.