Multivariate analysis evidenced seven factors significantly influencing tacrolimus log(C0/D) over D4-D7 (primary endpoint): recipient age at transplantation, the main cause of end-stage renal disease, CYP3A phenotype (encompassing the CYP3A5 *1, *3, *6, *7 the CYP3A4*22 and the POR*28 SNPs to account for ethnic diversity), dyslipidaemia at baseline and hematocrit, total bilirubin and plasma creatinine over the time period. This evidence concerns the gene CYP3A4 and inherited lipid metabolism disorder.