Multivariate analysis evidenced seven factors significantly influencing tacrolimus log(C0/D) over D4-D7 (primary endpoint): recipient age at transplantation, the main cause of end-stage renal disease, CYP3A phenotype (encompassing the CYP3A5 *1, *3, *6, *7 the CYP3A4*22 and the POR*28 SNPs to account for ethnic diversity), dyslipidaemia at baseline and hematocrit, total bilirubin and plasma creatinine over the time period. Here, CYP3A4 is linked to chronic kidney disease.