CYP3A4 and metabolic syndrome: Among the 21 factors considered in the multivariate model, those that influenced tacrolimus log (C0/D) in the FAS were: recipient age at baseline (p = 0.0144), the main cause of end-stage renal disease (p = 0.0092); CYP3A phenotype (p = 0.0001); dyslipidemia at baseline (p = 0.0031); and hematocrit (p = 0.0026), total bilirubin (p = 0.0261) and plasma creatinine (p = 0.0484) over the D4-D7 period (Table 3).