CYP3A4 and diabetes mellitus: Among the eight factors selected for the multivariate model, those that affected tacrolimus log (C0/D) in the FAS2 were: donor age (p = 0.0190), recipient age at baseline (p = 0.0083), CYP3A4 slow or intermediate phenotype (p < 10−20), diabetes at baseline (p = 0.0328) and ASAT over the time period (p = 0.0023), explaining 36.4% of the total variability (as compared with 46.9% for the IOV).