DisgeNET disease enrichment analysis (Figure 1B) disclosed several upregulated genes associated with Alzheimer’s disease (CSF1R, EPHB2, SERPINE1, PLPP4, COL4A4, LTBP2, IGFBP3, HHIP, DOCK2, CRISPLD2, DNER, ALOX5AP, NOX4, TGFBI, PROC, SMAD7, JUNB, ERG, and AMIGO2). This evidence concerns the gene PLPP4 and Alzheimer disease.