DisgeNET disease enrichment analysis (Figure 1B) disclosed several upregulated genes associated with Alzheimer’s disease (CSF1R, EPHB2, SERPINE1, PLPP4, COL4A4, LTBP2, IGFBP3, HHIP, DOCK2, CRISPLD2, DNER, ALOX5AP, NOX4, TGFBI, PROC, SMAD7, JUNB, ERG, and AMIGO2). The gene discussed is IGFBP3; the disease is Alzheimer disease.