Consistent with our hypothesis that Plin5 deficient animals on WD are healthier than WT controls, genera Oscillospiraceae NK4A214 that has been identified previously as a prognostic marker for obesity, various metabolic disorders and inflammatory bowel diseases was more enriched in WT animals of the MAFLD model (Burakova et al., 2022). The gene discussed is PLIN5; the disease is obesity due to melanocortin 4 receptor deficiency.