LDLR and Hypercholesterolemia: Studies on the link between LDLR-Ava II and/ or APOB-Xba I genotypes and hypercholesterolemia in several populations have yielded controversial results [26]; some reported a significant association between both gene polymorphisms and hypercholesterolemia [13], whereas others reported no such association [27]. Furthermore, several studies have recognized the connection between LDLR-Ava II and APOB-Xba I polymorphisms and elevated serum levels of TC and LDL-C [13, 28].