Ujiie et al have noted that BP180 or BP230-specific IgE antibodies, independent of IgG-mediated autoimmunity, are demonstrated to bind at the epidermal-dermal junction, inducing skin erythema and eosinophil infiltration via eosinophil degranulation in lesional tissue.4 The gene discussed is COL17A1; the disease is Autoimmunity.