Leonzino et al. (2016) has illustrated that the oxytocinergic signaling actively influences the functional dynamics of KCC2 by facilitating its phosphorylation and subsequent insertion/stabilization in the plasma membrane. Gigliucci et al. (2022) also reported a concomitant reduction in the KCC2 and OXTR expression in a mouse model of Rett syndrome. Additionally, it has been demonstrated that the down-regulation of KCC2 induced by lipopolysaccharide (LPS) led to a reduction in OXTR mRNA levels, highlighting a mutual relationship between oxytocin and chloride homeostasis (Tomita et al., 2022). The gene discussed is SLC12A5; the disease is Rett syndrome.