SLC12A5 and Anxiety: Rodent studies have shown that partial reduction and/or conditional deletion of KCC2 (both isoforms) led to spatial and nonspatial memory impairments, intracellular chloride accumulation, increased anxiety-like behaviors, seizure susceptibility, and hyposensitivity to thermal and mechanical stimuli but normal locomotor activity and motor coordination (Delpire and Mount, 2002; Tornberg et al., 2005; Kreis et al., 2023).