A recent study reported several pathogenic models through which RT may induce cardiac toxicity, including an inflammatory response mediated by pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1) and interleukin-6 (IL-6); endothelial dysfunction and fibrosis (4). The gene discussed is TNF; the disease is endothelial dysfunction.