Germline variants of homologous recombination deficiency (HRD) genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1, PALB2, RAD51C, and RAD51D, led to inherited susceptibility to specific types of cancer including breast cancer. This evidence concerns the gene PALB2 and breast carcinoma.