Among several junctional proteins that have been reported to interact either directly or indirectly with MTs(Vasileva and Citi 2018), the tight junction (TJ) protein cingulin (CGN) was reported to organize the Planar Apical Network (PAN) of MTs in Eph4 cells and promote apical lumen formation during cyst morphogenesis of MDCK cells by binding to MTs(Yano et al. 2013; Mangan et al. 2016). This evidence concerns the gene CGN and cyst.