TRPV1 and early-onset autosomal dominant Alzheimer disease: GSEA analysis showed significant enrichment of gene sets involved in Alzheimer’s disease, positive regulation of amyloid-β formation, leukocyte chemotaxis, unfolded protein stress and linoleic acid metabolism in microglia of TRPV1−/−/E4 (AAV-hTau) mice (Figs. 7a, b and S6f).