In the kidney cancer cohort (pan-kidney, clear cell renal cell carcinoma/chromophobe renal cell carcinoma/papillary renal cell carcinoma, KIRC/KICH/KIRP), we observed a dramatic shift of cell identities between NAT and tumor samples as well as among tumors of different histological types (Fig. 4F). This evidence concerns the gene BRD2 and papillary renal cell carcinoma.