In the kidney cancer cohort (pan-kidney, clear cell renal cell carcinoma/chromophobe renal cell carcinoma/papillary renal cell carcinoma, KIRC/KICH/KIRP), we observed a dramatic shift of cell identities between NAT and tumor samples as well as among tumors of different histological types (Fig. 4F). This evidence concerns the gene BRD2 and kidney cancer.