In the lung cancer cohort (pan-lung, lung adenocarcinoma/lung squamous carcinoma, LUAD/LUSC), in contrast to the observation that the NAT samples of the two diseases were uniformly enriched in AT2 cells, macrophages and fibroblasts, we uncovered a striking divergence of the cell states between LUAD and LUSC (Fig. 4K). Here, BRD2 is linked to lung adenocarcinoma.