MET and cancer: We then investigated the impacts of two major pan-kidney driver events [78, 79] on the cell state of the cancer types: VHL somatic mutations in KIRC contributed significantly to a cell state that favored S-shaped body medial cell (Fig. 4H), a known precursor for Henle’s loop and the distal tubule [80]; MET amplification was associated strongly with the accumulation of distal tubule progenitor cells in KIRP (Fig. 4I).