Moreover, miR-133a regulates insulin-like growth factor 1 (IGF-1) in the heart and regulates the etiology of insulin resistance; it was found that IGF-1 depletion reduces the phosphorylation of GATA binding protein 4, glucose transporter-4 (GLUT4), and protein kinase B (AKT) [11]. This evidence concerns the gene IGF1 and Insulin resistance.