Importantly, hMSCs delayed the onset of autoimmune diabetes in NOD mice via inhibiting Th1 polarization, however, promoting Treg generation, in TSG-6 dependent mechanism and the results might indicate the preventive function which MSC infusion or recombinant human TSG-6 could play in susceptible T1D individuals [38]. The gene discussed is TNFAIP6; the disease is type 1 diabetes mellitus.