Another RCT of 82 patients with essential hypertension showed that intervention of astragalus injection for 14 days could increase the serum expression levels of TAC, CAT and GSH-Px, reduce the serum expression levels of AOPP, decrease the serum expression levels of ET-1, sVCAM-1 and vWF, decrease the levels of VIO and baPWV, and increase the level of FMD. Here, EDN1 is linked to hypertensive disorder.