For SHR induced by high fat diet, transcatheter radiofrequency ablation of renal sympathetic nerve can continuously reduce SBP and DBP, lower serum AngII, NADPH oxidase and MDA levels at various postoperative time points, increase eNOS and NO content, thereby reducing SNS activity, inhibiting oxidative stress, and treating hypertension [21]. The gene discussed is AGT; the disease is hypertensive disorder.