In 2 kidneys and 2 clamps rats (2K2C) prone to renal vascular stroke and hypertensive rats induced by AngII, ginsenoside Rd can reduce the expression and activity of Nox1 and Nox2 proteins in NADPH oxidase subunits, inhibit AngII induced NO production, and reduce ROS production, which in turn improve vascular endothelial damage in hypertension [35]. The gene discussed is FMO5; the disease is Hypertension.