SOD2 and Glomerular sclerosis: The intervention of Tongxinluo capsule for 12 weeks can increase creatinine clearance of SHR, reduce urine albumin, reduce glomerular sclerosis, renal podocyte damage and tubular interstitial fibrosis, reduce MDA levels and increase manganese Manganese superoxide dismutase (Mn-SOD) and CAT levels.