A RCT involving 174 patients with hypertension and type 2 diabetes has shown that, in addition to significantly reducing SBP and DBP, Tongxinluo capsule can also reduce fasting blood glucose and 2 h postprandial blood glucose levels, increase SOD, NO, GSH-Px and CAT levels, and decrease MDA and ET-1 levels [244, 245]. The gene discussed is EDN1; the disease is hypertensive disorder.