SOD1 and Hypertension: The mechanism may be related to the inhibition of the abnormal increase of AngII induced by hypertension and the abnormal activation of TGF-β1 signaling pathway, reduction of MDA level, increase of SOD level, inhibition of proliferation of mouse embryonic fibroblasts (NIH3T3), reduction of collagen secretion and the expression of type 1 collagen [69].