Experimental studies based on the two-kidney and two-clamp (2K2C) stroke-prone nephrovascular hypertension rat model (RRSP) showed that ligustrazine can down-regulate the levels of ET-1 and AngII, up-regulate the levels of NO, and improve the basilar artery remodeling in RRSP rats. The gene discussed is EDN1; the disease is hypertensive disorder.