For SHR induced by high fat diet, transcatheter radiofrequency ablation of renal sympathetic nerve can continuously reduce SBP and DBP, lower serum AngII, NADPH oxidase and MDA levels at various postoperative time points, increase eNOS and NO content, thereby reducing SNS activity, inhibiting oxidative stress, and treating hypertension [21]. This evidence concerns the gene NOS3 and Hypertension.