Zheng S et al. showed that Fzd5 differs from other Fzd proteins in that its conserved extracellular chain region binds cholesterol, which in pancreatic ductal adenocarcinoma (PDAC) promotes the growth of cancer cells through the activation of the Wnt/β-catenin signaling pathway by Fzd5 (Zheng et al. 2022). The gene discussed is FZD5; the disease is pancreatic ductal adenocarcinoma.