Borrell-Pagès M et al. found that the transcriptional regulation of LRP5 is influenced by aggregated low-density lipoprotein (agLDL) and that LRP5 is involved in macrophage lipid uptake and transformation to foam cells, which play a key role in influencing the onset and progression of atherosclerosis (Borrell-Pagès et al. 2011). Here, LRP5 is linked to atherosclerosis.