Xuemin He et al. demonstrated that the development of autosomal dominant polycystic kidney disease (ADPKD) is closely associated with the LRP5 variant, which has been observed to be involved in the development of tubular fibrosis through the direct regulation of the TGF-β/Smad signaling pathway (He et al. 2020). Here, LRP5 is linked to autosomal dominant polycystic kidney disease.