Marilena Carrino et al. found that the survival of multiple myeloma (MM) cells is also closely related to CK1, and that by inhibiting CK1 activity or lowering the level of CK1, autophagic activity and promoting apoptosis in multiple myeloma cells can be reduced, thereby inhibiting tumor growth and survival (Carrino et al. 2019).Yumeng Zhang et al. demonstrated that nicotinamide promoted the differentiation of pancreatic progenitor cells by inhibiting CK1 and ROCK, and demonstrated that inhibition of CK1α and CK1ε promoted the differentiation of pancreatic progenitor cells (Zhang et al. 2021). Here, CSNK1A1 is linked to AL amyloidosis.