Shu Ma et al. demonstrated that in ankylosing spondylitis, microRNA-96 (miR-96) improves osteoblast differentiation and bone formation through activation of the Wnt signaling pathway, which was achieved by up-regulating the expression of Wnt1, β-catenin, and GSK-3β, as well as induced phosphorylation of β-catenin and GSK-3β activating the Wnt/β- catenin signaling pathway is achieved (Ma et al. 2019). The gene discussed is GSK3B; the disease is ankylosing spondylitis.