Lingling Liu et al. found that mutations in the Dvl gene were present in human patients with neural tube defects and Dandy-Walker malformations, which resulted in blockage of the Wnt/β-catenin signaling pathway, in addition to the finding that only the Dvl2 p.R633W mutation showed more severe malformations in zebrafish embryos when compared to wild-type Dvl2 toxicity, revealing the important role of Dvl mutations in the pathogenesis of human neurological diseases (Liu et al. 2020). This evidence concerns the gene DVL1 and nervous system disorder.