In addition, Wnt2 has also been associated with immunocompetence, and Tu-Xiong Huang et al. showed that Wnt2 secreted by cancer-associated fibroblasts (CAFs) inhibits dendritic cell-mediated antitumour T-cell responses through the SOCS3/p-JAK2/p-STAT3 signaling cascade (Huang et al. 2022).Wnt3 plays a role in embryonic development and neural tube formation. The gene discussed is WNT2; the disease is cancer.