However, according to the currently known information, CK1 plays an important role in the Wnt/β-catenin signaling pathway, which is closely related to the processes of cell proliferation and differentiation, etc. Although it is not clear that there is a relationship between CK1 and the pathogenesis of osteoporosis, from the aspect of its biological roles, we can hypothesize that there exists a little bit of a link between CK1 and osteoporosis, so that in the future research can further explore the potential role of CK1 in the pathogenesis of osteoporosis. The gene discussed is CSNK1A1; the disease is osteoporosis.