Recently, Xue Wang et al. found that BM was able to regulate the Wnt/β-catenin signaling pathway by increasing the expression of LRP6, Wnt3a and β-catenin as well as decreasing the expression of GSK-3β to promote osteoblasts differentiation attenuating the loss of bone mass and improving bone turnover in OVX-induced osteoporosis in mice (Wang et al. 2022a, b). This evidence concerns the gene LRP6 and osteoporosis.