On the other hand, Sixu Chen et al. demonstrated that the therapeutic effect of PTH is attenuated in mice with type 1 diabetes, but when pre-activated with β-catenin in osteoblasts enhanced the anabolic effect of PTH on bone in mice with type 1 diabetes, significantly improving bone structure, bone volume and bone strength (Chen et al. 2020a, b). Here, PTH is linked to type 1 diabetes mellitus.