WNT1 and colorectal cancer: On the contrary, Guang-Lin Song et al. found that the microRNA miR-130a-3p (miR- 130a-3p) directly targets Wnt1, and miR-130a-3p can inhibit colorectal cancer(CRC) growth by reducing Wnt1 expression, suggesting a potential microRNA-based therapeutic strategy (Song et al. 2021).