PECAM1 and colonic neoplasm: DM induces the shedding of platelet-endothelial cell adhesion molecule 1 (PECAM-1) from endothelial cells and its internalization and aggregation around the nucleus of the cells, which leads to the entry of β-catenin into the nucleus of the cells to promote the progression of colon cancer and endothelial-mesenchymal transition(EndMT) (Wu et al. 2023).