STAT3 and cancer: Transcription factors (TFs) stand as the central regulator to the cellular gene expression (Regev, et al. 2017; Wu et al. 2020) TFs such as STAT3 play critical roles in cellular processes ranging from differentiation to proliferation, and in the context of cancer, they are key players in driving tumorigenesis and metastasis (Tolomeo and Cascio 2021; Ma, et al. 2022).