Overall, this study explored natural products as potential anti-cancer agents, particularly focusing on xanthohumol and its effects on osimertinib-resistant NSCLC cells, which highlighted how xanthohumol targets the Ets-1/c-Met signaling pathway and interferes with USP9X binding to Ets-1, thereby inhibiting tumor growth. The gene discussed is ETS1; the disease is non-small cell lung carcinoma.