DDIT4 and head and neck squamous cell carcinoma: For example, in head and neck squamous cell carcinoma (HNSCC), a novel m6A-binding protein, RBM33, can interact with ALKBH5 to regulate the stability of DDIT4 mRNA in a m6A-dependent manner, thereby promoting DDIT4-mediated autophagy, which maintains the tumorigenicity of HNSCC both in vitro and in vivo [60].