ALKBH5 and gastric cancer: Similarly, in GC, a ubiquitously expressed multifunctional zinc-finger transcription factor, Yin-Yang 1, is regulated by m6A modifications mediated by ALKBH5 and YTHDF1, activating the ATG4B-dependent autophagy pathway and thereby promoting the viability, proliferation, and migratory activity of GC cells [56].