Together these results indicate that, in 14-3-3ζ+++ cancer cells, low-nutrient- or chemotherapy-induced stresses stabilize NLK protein to induce pS128-Yap1 that releases 14-3-3ζ-bound Yap1 for nuclear translocation and activation, leading to CXCL2/5 upregulation. This evidence concerns the gene CXCL2 and cancer.