Since CXCL2/5 derived from stressed 14-3-3ζ+++ PDAC cells is critical for maneuvering PSCs/fibroblasts, and Cox2 induction in PSCs/fibroblasts is part of the adaptive response (Fig. 1g; Supplementary Fig. S6a–d), we investigated whether upregulated CXCL2/5 from stressed 14-3-3ζ+++ cancer cells causally induce Cox2 expression in PSCs/fibroblasts by gain- and loss-of-function studies. This evidence concerns the gene PTGS2 and cancer.