CXCL2 and cancer: To identify 14-3-3ζ+++ cancer cell-secreted factors that activate PSCs/fibroblasts, CM from Panc02.shCtrl and Panc02.shζ cells (0% FBS culture) were profiled for cytokine secretions, revealing elevated levels of CXCL2 and CXCL5 in CM from 14-3-3ζ+++ Panc02.shCtrl cells (Fig. 3a).