Interestingly, in patients with low-stage GBC with UICC2, the tumor epithelium was positive in all cases, whereas in later-stage GBC, denoted by UICC3 and UICC4, the GBC epithelium was negative in more than one-third of patients suggesting that CEACAM6 is early in carcinogenesis upregulated but not required or even has negative effects in advanced stage GBC (Fig. 1K). The gene discussed is CEACAM6; the disease is neoplasm.