As individuals who are obese or have T2D have lower levels of SHBG [65, 66] and emerging evidence suggests that SHBG may be an indicative marker of cardiometabolic disease risk, including risk of IR, obesity, T2D and other metabolic disorders [10, 67, 68], the influence of exercise on SHBG and its association with anthropometric measures should be further investigated. The gene discussed is SHBG; the disease is metabolic disease.