Meta-analysis of two studies in men, which included a total of 44 participants (28 with obesity, 16 with T2D), total intervention groups n = 3, and two studies in women who were obese with a total of 19 participants, were analysed for the effects of aerobic exercise training on SHBG [37, 45, 47, 48]. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.