This study demonstrated that exercise markedly upregulated circFndc3b expression in microglia/macrophages within the peri‐infarct region, leading to the suppression of NLRP3 inflammasome‐driven microglial/macrophage pyroptosis and subsequent neuroinflammation, while also improving post‐stroke neurological deficits. Here, NLRP3 is linked to Stroke.