Klf2, a transcription factor, is crucial in various biological processes such as adipogenesis, lung development, and T‐cell survival.[53, 54] Klf2 has shown protective effects in ischemic stroke, where it promotes post‐stroke angiogenesis[55] and activates the IRF4/HDAC7 axis to reduce neuronal injury.[56] However, its role in neuroinflammation following ischemic stroke remains unclear. This evidence concerns the gene IRF4 and ischemic stroke.