KLF2 and ischemic stroke: In vitro rescue experiments indicated that Klf2 inhibition (siKlf2) after OGD/R reversed the suppression of NLRP3 and GSDMD‐N expression caused by circFndc3b overexpression (P = 0.0011, P = 0.0049, respectively, Figure 7J), confirming that circFndc3b exerts its neuroprotective effects via Klf2 upregulation following ischemic stroke.