CD40LG and hepatocellular carcinoma: reported that B cells derived from HCC blood were mainly CD45RA+IgD+IgM+IgG−BTLA+ and functionally incompetent.[28] In this scenario, we preliminarily inquired about the possible roles of the characteristics of B cells in situ, mIHC results demonstrated that there were more B cells in the immunotherapy‐responsive tumors and the majority of B cells were involved in constituting TLS.