Comparable to the results for other tumor types, administration of anti‐CD20 antibody to mice reduced the therapeutic efficacy of anti‐PD‐1antibody against liver tumor of Hepa1‐6 cells (Figure S8A‐C, Supporting Information), as well as inhibited proliferation (Ki‐67) and tumor‐killing activity by downregulating IFN‐γ, Perforin and upregulating PD‐1 of the tumor‐infiltrating CD8+T cells (Figure S8D‐F, Supporting Information). Here, PRF1 is linked to neoplasm.