On day 15 postimplantation, CRT expression and HMGB1 cytoplasmic translocation were much higher in the “APHP‐CCCA+808+660” group compared to other groups (Figure S6D,G,H, Supporting Information), demonstrating that APHP‐CCCA‐mediated in vivo phototherapy could efficiently elicit ICD. This evidence concerns the gene HMGB1 and impulse control disorder.