CALR and neoplasm: ICD is a unique form of cell death that can release immunogenic damage‐associated molecular patterns (DAMPs) and tumor‐associated antigens, triggering long‐term protective antitumor immune responses.[25] The expression levels of calreticulin (CRT) and subcellular localization of high mobility group box 1 (HMGB1) in tumor tissues after different treatments were analyzed by immunohistochemical staining (Figure 4F; Figure S6D–H, Supporting Information).