CD4 and neoplasm: We next examined the levels of tumor regulatory T cells (Tregs, CD3+CD4+Foxp3+), which can suppress the antitumor immune responses of cytotoxic T lymphocytes and induce an immunosuppressive microenvironment.[27] The results demonstrated that the Tregs frequency in the “APHP‐CCCA+808+660” group was 3.5‐fold lower than in the PBS group on day 15, indicating effective reduction of tumor‐associated immunosuppression (Figure 4J).