In another cohort (GSE41252) encompassing primary tumors but also liver and lung metastatic CRC samples, we observed that the expression of MICU1 is down-regulated while both MICU2 expression and the MICU2/MICU1 ratio are significantly up-regulated in liver metastasis of CRC (Figs 1B and S1B). This evidence concerns the gene MICU1 and colorectal carcinoma.