RUNX2 and cancer: Similarly, gene set enrichment analysis on the automated-method-derived Fabry samples(Fig 6D) showed enrichment in pathways related to RUNX1 and RUNX2 regulations and activities, heart development, negative regulation of angiogenesis, and MAPK signaling pathways, which have been reported to be associated with various angiogenesis-related disorders such as cancer, cardiomyopathy, nephropathy, and retinopathy [24–27].