Among CRC patients treated with stage I-IV surgery, univariate analysis showed that preoperative mSEPT9 positivity (HR: 9.297, 95% CI: 2.77–31.199, P<0.05), CEA>5 ng/ml (HR: 3.021, 95% CI: 1.26–7.242, P<0.05), late TNM staging (HR: 19.251, 95% CI: 2.6–142.522, P < 0.05) were connected with shorter RFS in patients. This evidence concerns the gene CEACAM5 and colorectal carcinoma.