Studies have shown that overexpression of SEPT9 attenuates myofibroblast biomarkers α-SMA and Col1a1 expression induced by TGF-β1, goes together with the upregulation of proteins associated with apoptosis, and slows down activation of hepatic stellate cells, so drugs that suppress the methylation and elevate the expression of SEPT9 hold promise for clinical application in the management of hepatic fibrosis [25]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.