As shown in Fig 7, FOS (AUC: 0.962, confidence interval (CI): 0.910–1.000), SIRT1 (AUC: 0.969, CI: 0.926–1.000), MAP2K1 (AUC: 0.842, CI: 0.740–0.944), PIK3CA (AUC: 0.969, CI: 0.927–1.000), RB1 (AUC: 0.903, CI: 0.823–0.983), EIF2AK3 (AUC: 0.979, CI: 0.941–1.000), and PTGS2 (AUC: 0.840, CI: 0.742–0.937) had high diagnostic values in CKD related to PANoptosis. The gene discussed is EIF2AK3; the disease is chronic kidney disease.