SNCA and Parkinson disease: Fasudil has been shownto attenuate alpha-synuclein aggregation in in vivo models of Parkinson’s disease at low doses, although NMRtitration experiments suggest Fasudil shows a relatively weak dissociationconstant in the 1–3 mM for alpha-synuclein.18 Basu et al. have also reported a similar disconnect betweenthe ca. 5 mM binding constant of the small molecule EPI-001 for thetransactivation domain of the androgen receptor measured by NMR, anda ca. 5 μM IC50 activity in a luciferase reportercell assay.19 Heller et al. determined,by NMR titration experiments, a Kd ofca.