Severe asthma is often associated with Th2 low and mixed endotype, increased neutrophils and extracellular DNA (eDNA) in patient sputum, with an increase in type 1 cytokines IL‐1β and IL‐6 at the late onset of the disease, and unresponsiveness to corticosteroids or specific biologicals.1, 3, 4, 5, 6. The gene discussed is IL6; the disease is asthma.