Among the genes (that were affected by at least three different CBD treatments), CBD downregulated the expression of, e.g., the BGN gene that encodes Biglycan, which is a secreted proteoglycan that is involved in collagen fibril assembly, while its fragmentation is likely to be associated with collagen turnover during the pathogenesis of diseases that involve dysregulated extracellular matrix remodeling (ECMR), such as liver fibrosis (Ciftciler et al. 2017). The gene discussed is BGN; the disease is Hepatic fibrosis.